Authors: Dr. John Jiang, Dr. Wang Fang | San Diego Global R&D & Quality HQ
Without AGPs, the intestinal villi are more susceptible to atrophy, and the "Tight Junction" proteins that seal the gut wall often weaken. This leads to "Leaky Gut Syndrome," allowing pathogens like E. coli and Salmonella to translocate into the bloodstream, causing systemic inflammation and poor FCR.
GutPlus™ utilizes a specialized silica carrier loaded with 15% Short-chain Fatty Acids (SCFAs) and organic acid complexes. These molecules serve as the primary energy source for colonocytes, promoting villi growth and increasing the thickness of the protective mucus layer. Our trials show a 22% increase in villi height-to-crypt depth ratio.
While GutPlus™ handles the physical barrier, ImmunoGuard™ activates the biological defense. Containing 20% bioactive nucleotides and modified β-glucans, it triggers the recruitment of macrophages and strengthens the response to vaccinations. This is critical during high-stress periods like nursery transitions or seasonal climate shifts in SE Asia.
A multi-stage trial conducted in a high-density broiler farm in Thailand compared the SILSEP synergy against a standard AGP program.
| Metric | Standard AGP Program | SILSEP Synergy (Gut+Immuno) | Improvement |
|---|---|---|---|
| Intestinal Lesion Score (0-4) | 1.2 | 0.4 | -66.7% |
| Antibody Titer (NDV Vaccination) | 8.2 log2 | 9.5 log2 | +15.8% |
| Mortality Rate (0-42 Days) | 3.5% | 2.1% | -40.0% |
| Final FCR | 1.58 | 1.52 | -0.06 |
The combination of mechanical reinforcement (GutPlus™) and biological activation (ImmunoGuard™) provides a robust alternative to AGPs. This molecular strategy not only maintains performance but enhances the animal's natural resilience to tropical disease pressures.